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KMID : 1040620170230010042
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Clinical and Molecular Hepatology
2017 Volume.23 No. 1 p.42 ~ p.50
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The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE
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Kim Jung-Hee
Sinn Dong-Hyun
Shin Sung-Wook
Cho Sung-Ki
Kang Won-Seok
Gwak Geum-Youn
Paik Yong-Han
Lee Joon-Hyeok
Koh Kwang-Cheol
Paik Seung-Woon
Choi Moon-Seok
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Abstract
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Background/Aims: We investigated the outcomes of early-stage hepatocellular carcinoma (HCC) patients who showed a complete response (CR) to initial transarterial chemoembolization (TACE), with a focus on the role of scheduled TACE repetition.
Methods: A total of 178 patients with early-stage HCC who were initially treated with TACE and showed a CR based on the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria on one month follow-up computed tomography (CT) were analyzed. Among them, 90 patients underwent scheduled repetition of TACE in the absence of viable tumor on CT.
Results: During a median follow-up period of 4.6 years (range: 0.4-8.8 years), mortality was observed in 71 patients (39.9%). The overall recurrence-free and local recurrence-free survival rates at 1 year were 44.4% and 56.2%. In the multivariable model, scheduled repetition of TACE was an independent factor associated with survival (hazard ratio [95% confidence interval]: 0.56 [0.34-0.93], P=0.025). When stratified using Barcelona clinic liver cancer (BCLC) stage, scheduled repetition of TACE was associated with a favorable survival rate in BCLC stage A patients, but not in BCLC 0 patients.
Conclusions: Scheduled repetition of TACE was associated with better survival for early-stage HCC patients showing a CR after initial TACE, especially in BCLC stage A patients.
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KEYWORD
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Carcinoma, Hepatocellular, Transarterial chemoembolization, Survival
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